Comment: Concern about Figure 5D: Blue boxes: In the Hippocampus row, two panels representing different treatments unexpectedly overlap This paper was found as part of a Science investigation published by Charles Piller today: Picture Imperfect: Scores of papers by Eliezer Masliah, prominent neuroscientist and top NIH official, fall under suspicion. "After Science brought initial concerns about Masliah’s work to their attention, a neuroscientist and forensic analysts specializing in scientific work who had previously worked with Science produced a 300-page dossier revealing a steady stream of suspect images between 1997 and 2023 in 132 of his published research papers." The illustrations shown here are the result of a collaborative effort of Drs. Matthew Schrag, Mu Yang, Elisabeth Bik, and Mr. Kevin Patrick and reflect our collective opinions. Several figures in this paper appear to have problems - some more might be posted later by others.

Author : Elisabeth M Bik

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Abstract: <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Immunotherapeutic approaches targeting amyloid β (Aβ) protein and tau in Alzheimer's disease and α‐synuclein (α‐syn) in Parkinson's disease are being developed for treating dementia with Lewy bodies. However, it is unknown if single or combined immunotherapies targeting Aβ and/or α‐syn may be effective.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Amyloid precursor protein/α‐syn tg mice were immunized with AFFITOPEs® (AFF) peptides specific to Aβ (AD02) or α‐syn (PD‐AFF1) and the combination.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>AD02 more effectively reduced Aβ and pTau burden; however, the combination exhibited some additive effects. Both AD02 and PD‐AFF1 effectively reduced α‐syn, ameliorated degeneration of pyramidal neurons, and reduced neuroinflammation. PD‐AFF1 more effectively ameliorated cholinergic and dopaminergic fiber loss; the combined immunization displayed additive effects. AD02 more effectively improved buried pellet test behavior, whereas PD‐AFF1 more effectively improved horizontal beam test; the combined immunization displayed additive effects.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Specific active immunotherapy targeting Aβ and/or α‐syn may be of potential interest for the treatment of dementia with Lewy bodies.</jats:p></jats:sec>

Zones détectées : blue

Date : 12/12/2023